Meg Murry can't help worrying when her six-year-old brother, Charles Wallace, announces that there are dragons in the vegetable garden. He's so bright, and so different from other kids, that he's being bullied at school, and he is also strangely, seriously ill.
But Charles Wallace is right about the dragons—actually a friendly entity who has come to help Charles Wallace fight his sickness, and to take Meg and her friend Calvin O'Keefe on a terrifying, wonderful journey into galactic space, where they must battle the forces of evil to save Charles Wallace and themselves.
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