Born in India in 1863, Rouse later attended the University of Cambridge, studying the Classical Tripos and Sanskrit. A scholar and a classicist, Rouse spent six years as a Fellow of Christ's College, Cambridge before becoming a school teacher at Rugby School. There, among other accomplishments, he aided the future author Arthur Ransome in writing until an opportunity to teach and be the headmaster of The Perse School, Cambridge presented itself. Rouse accepted the challenge and led the financially beleaguered institution into stability.
As an educator Rouse encouraged students to learn visually, orally, and kinetically. He also emphasized the importance of observation and experimentation in the fields of science. Rouse advocated the Direct Method of teaching Latin and Greek and pioneered summer classes for teachers to learn how to teach this method. Given his background as a classical scholar, Rouse was chosen with two other men to be the founding editors of the Loeb Classical Library. As an author Rouse translated classical works into English such as Homer's The Iliad and The Odyssey and Plato's Dialogues. He also published songs in Greek and Latin called "Chanties." Rouse stayed busy translating even through his retirement and passed away in 1950.